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HomeTOP NEWSSCIENCE & ENVIRONMENTScientists Explain why chronic stress triggers behaviour problems like depression and loss...

Scientists Explain why chronic stress triggers behaviour problems like depression and loss of enjoyment.


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WASHINGTON: It’s It is clear that chronic stress Our behavior can have an impact on our lives, which can lead to problems such as DepressionThe result is a decreased interest in things we used to enjoy, and even PTSD.
Now Scientists Evidence has shown that neurons located in the bow-shaped brain area become hyperactive following an event. chronic Stress exposure When These POMC neurons are super active and can cause behavior problems. Scientists report how they reduce the activity in the journal. Molecular Psychiatry.
Scientists At the Medical College This is Georgia At Augusta University In response to 10 days’ of unpredictable, chronic stress, we looked at the hypothalamus. This is the key to hormone release and regulation of hunger, thirst, and sex drive. Chronic The study of stress in animal models is often done using unpredictable stress. This included restraints, prolonged wet bedding in a tilted enclosure, and social isolation.
They According to the corresponding author, stressors led to spontaneous firing of POMC neurons in female and male mice. Xin-Yun LuChair of the MCG: Dr., Ph.D. Department This is Neuroscience Regenerative Medicine Georgia Research Alliance Eminent Scholar In Translational Neuroscience.
When They activated the neurons directly, instead of letting stress increase their firing. It also caused an apparent inability feel pleasure (called anhedonia) and behavioral despair which is basically depression. In For humans, anhedonia could indicate a lack of interaction with good friends and a loss in libido. In The usual love of sugar water wains is lost in mice. Male mice who, when they’re hot, like to smell the urine of females, lose some interest.
Conversely The MCG scientists lowered stress-induced behavior changes by inducing neurons to fire.
The Results indicate that POMC neurons are present “both necessary and sufficient” Stress can increase susceptibility, which in turn leads to increased stress-related firing. This is what causes behavioral changes such as depression. In Fact is, stress has been shown to decrease inhibitory inputs into POMC neurons. Lu says.
The The POMC neurons are located in the hypothalamus’ arcuate nucleus (or ARC) which is a bow-shaped brain area that has been shown to have an important role in chronic stress and how it affects behavior.
Occupying Another population of neurons is found in the same area, known as AgRP neurons. These neurons are crucial for depression and chronic stress resilience. Lu She and her team reported on Molecular Psychiatry In the early 2021.
In Chronic stress is a constant reality. Lu’s Lab research has shown that AgRP activation decreases when behavioral changes such as anhedonia occur. It was also found that the stimulation of those neurons reduced these behaviors. Her Team also wanted to understand what chronic stress does to POMC neurons.
The role of AgRP neurons in our hunger-stricken search for food is well-known. However, they are also known to be in a yin/yang relationship with POMC neurons. When AgRP activation goes up, for example, POMC activation goes down.
“If you stimulate AgRP neurons it can trigger immediate, robust feeding,” Lu says. Food These neurons also fire more when there is less of it. It’s It is also known that AgRP neurons transmit messages to POMC neurons, in order to let go of the inhibition on feeding, when they are excited by hunger signals.
Their Research has shown that chronic stress causes disruption to the yin-yang balance of these two neuronal groups. Although AgRP’s projection on POMC neuron firing activity is evidently important. This intrinsic mechanism is most likely the major mechanism behind hyperactivity of POMC neuron by chronic stress. Lu says.

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